Lesser-Known Biomarkers That Define Pitta's Temperament
One very exasperating aspect of science is the lack of advancements. We meet a biomarker and marry it like a polygamist.
Modern science has long relied on a narrow set of biomarkers to explain complex physiological states. Conventional markers like cortisol, serotonin, and dopamine often fall short of capturing the full picture. We need to look at other targets. This is what I call “under-the-radar” biomarkers. Those molecules expressed in either undetectable quantities or unrecognizable by our detection methods.
AKScientist’s ayurvedic research recognizes its individualized and holistic approach, suggesting that there are many under-explored biomarkers. Here, I briefly cover just five potential biomarkers that can be used for therapeutics.
BDNF, neuropeptide Y, indoleamine 2,3-dioxygenase (IDO), alpha-MSH, and glutathione, for example, could provide richer insights into health. With advances in genomics, proteomics, metabolomics, and neuroimaging, there is now an exciting opportunity to validate and integrate these alternative markers, potentially reshaping our understanding of physiology.
To make it simple, I focus on one dosha: Pitta. To further simplify this topic, I focus on one Pitta characteristic: temperament.
Pitta’s volatile temperament is often associated with stress related to a demanding workload. Both are relevant conditions for current living standards. But little has been established to effectively address them.
THE SCIENCE
Beyond cortisol and serotonin, several lesser-known biomarkers play a role in emotional regulation, stress response, and cognitive function. BDNF and GSH you probably have heard of due to the ever-pervasive supplement industry. But three here are widely unknown to the general public. The people who can greatly benefit from regulating them.
Brain-Derived Neurotrophic Factor
Low levels of BDNF are linked to stress-induced neurodegeneration. Synaptic plasticity and cognitive function can be supported through BDNF activity with neuroprotective herbs like gotu kola and brahmi because they are beneficial for sustaining mental resilience. (Neuroprotective here translates to the commonly used Ayurvedic term “cooling”)
Neuropeptide Y
The stress-buffering neurotransmitter NPY enhances emotional resilience. Unrestrained pitta-related neurochemical activity can give rise to NPY depletion, increasing anxiety and impatience. Regular mindfulness and sheetali pranayama help restore optimal levels. (Unrestrained neurochemical activity here translates to the commonly used Ayurvedic term “unbalanced”.)
Indoleamine 2,3-Dioxygenase
IDO regulates tryptophan metabolism, influencing serotonin production. Chronic inflammation increases IDO activity, leading to serotonin depletion and mood instability. Probiotics like Lactobacillus plantarum have anti-inflammatory properties that help modulate IDO activity. (Anti-inflammatory here translates to “cooling” in Ayurveda.)
Glutathione
GSH is a master antioxidant that protects against oxidative stress. Elevated oxidative metabolism characteristic of Pitta can deplete GSH, leading to cellular inflammation and burnout. Ayurvedic herbs like amla and guduchi support GSH synthesis. (Oxidative metabolism here translates to “excess Pitta”.)
Alpha-Melanocyte Stimulating Hormone
α-MSH regulates anti-inflammatory responses and mood stability. Suppressed α-MSH expression due to heightened inflammatory signaling, can lead to heightened emotional reactivity. Hydrating and anti-inflammatory foods like coconut water and cucumber may help regulate α-MSH levels and restore homeostasis. (The type of heightened inflammatory signaling here translates to what Ayurveda recognizes as “Pitta imbalance”.) (Hydrating and anti-inflammatory translates to “cooling”.)
BOTTOM LINE
Modern science must expand beyond the familiar biomarkers to embrace a broader spectrum of molecular signatures. By integrating emerging high-throughput techniques with Ayurvedic diagnostic frameworks, researchers can uncover novel biomarkers currently overlooked by conventional methods. This approach not only holds promise for enhancing diagnostic precision but also demonstrates how Ayurveda could benefit from incorporating these advanced insights. In doing so, we pave the way for a more nuanced model of personalized healthcare that bridges the gap between ancient wisdom and contemporary science. This is in the portfolio for AKScientist Research.
